Rosacea glandular-hyperplastic L71.8

Late stage of rosacea (stage III rosacea), which usually presents with other symptoms of rosacea

Phymbogenesis occurs almost exclusively in men.

The clinical picture is characterized by hyperplasia of sebaceous glands and connective tissue. This can lead to a diffuse, bulging coarsening of the skin relief, or to circumscribed nodular changes (phymogenesis) which occur mainly on the nose (see below: rhinophyma), cheeks, chin(gnathophyma), forehead(metophyma), ears(otophyma) or very rarely on the eyelids (blepharophyma).

It is still unclear whether the formation of phymas is associated with an increased risk for the development of basal cell carcinomas.

1. Alcántara ripening CM et al.(2016) Otophyma: a rare variant of phymatous rosacea. At J Otolaryngol 37:251-254.
2. Dahl MV (2004) Rosacea subtypes: a treatment algorithm. Cutis. 2004 Sep;74 (3 Suppl):21-27. https://www.ncbi.nlm.nih.gov/pubmed/15499755
3. Hopkinson D et al(2015) Assessment of rosacea severity: A review of evaluation methods used in clinical trials. J Am Acad Dermatol 73:138-143. https://www.ncbi.nlm.nih.gov/pubmed/25799418
4. Strauss RM et al (2006) An oedematous lesion in the nasolabial fold. Diagnosis: phymatous lesion with underlying rosacea. Clin Exp Dermatol 31:729-730.
5. Voth H et al (2013) Phymatous transformation of facial cutaneous vascular malformations: clues to phyma pathogenesis. JAMA Dermatol. 149:368-369.