Rosacea glandular-hyperplastic L71.8

Late stage of rosacea (stage III rosacea), which usually presents with other symptoms of rosacea

At 71.8%, phyma formation occurs predominantly in men (Hoepfner A et al. 2020).

The average age at diagnosis is 60.3 years (26-84) (Hoepfner A et al- 2020).

The clinical picture is characterized by hyperplasia of sebaceous glands and connective tissue. This can lead to a diffuse, bulging coarsening of the skin relief, or to circumscribed nodular changes (phymogenesis) which occur mainly on the nose (see below: rhinophyma), cheeks, chin(gnathophyma), forehead(metophyma), ears(otophyma) or very rarely on the eyelids (blepharophyma).

It is still unclear whether the formation of phymas is associated with an increased risk for the development of basal cell carcinomas.

1. Alcántara-Reifs CM et al.(2016) Otophyma: a rare variant of phymatous rosacea. Am J Otolaryngol 37:251-254.
2. Dahl MV (2004) Rosacea subtypes: a treatment algorithm. Cutis. 2004 Sep;74 (3 Suppl):21-27. https://www.ncbi.nlm.nih.gov/pubmed/15499755
3. Hoepfner A et akl. (2020) Rosacea and perioral dermatitis: a monocentric, retrospective analysis of the clinical presentation of 1032 patients. J Dtsch Dermatol Ges 18:561-570.
4. Hopkinson D et al.(2015) Assessment of rosacea severity: A review of evaluation methods used in clinical trials. J Am Acad Dermatol 73:138-143. https://www.ncbi.nlm.nih.gov/pubmed/25799418
5. Strauss RM et al. (2006) An oedematous lesion in the nasolabial fold. Diagnosis: phymatous lesion with underlying rosacea. Clin Exp Dermatol 31:729-730.
6. Voth H et al. (2013) Phymatous transformation of facial cutaneous vascular malformations: clues to phyma pathogenesis. JAMA Dermatol. 149:368-369.