Rifabutin

Definition
This section has been translated automatically.

Indication
This section has been translated automatically.

Tuberculosis, infections by atypical mycobacteria (MAI), prophylaxis of MAI infection in HIV patients with < 200 CD4 cells/μl.

You might also be interested in

Dermatology

type i neurofibromatosis, peripheral type or classic cutaneous form. numerous smaller and larger ...

Neurofibromatosis (overview)

Group of hereditary, autosomal-dominantly inherited or spontaneously mutated neuroectodermal systemic disea...

Advertisment

Limited indication
This section has been translated automatically.

Pregnancy, lactation, children < 14 years, severe liver and kidney failure.

Dosage and method of use
This section has been translated automatically.

Tuberculosis (combination therapy): 150 mg/day p.o., in case of immunosuppression 300 mg/day p.o.

MAI: 300 mg/day p.o. for up to 6 months after achieving negative cultures; in combination with clarithromycin, other macrolides or triazole antifungals 300 mg/day. In combination with indinavir: 150 mg/day p.o.

MAI prophylaxis: 300 mg/day p.o.

Reminder. Patients with soft contact lenses must be informed about the possibility of permanent discolouration of the lenses!

Undesirable effects
This section has been translated automatically.

Allergic reactions, skin discoloration and discoloration of body excretions after red-orange, headaches, sleep disorders, uveitis, chest pain, anemia, eosinophilia, leukopenia, neutropenia, thrombopenia, abdominal pain, myalgias.

Interactions
This section has been translated automatically.

See Table 1.

Contraindication
This section has been translated automatically.

Rifamycin hypersensitivity, acute hepatitis or cirrhosis of the liver, occlusive scterus, thrombocytopenia.

Preparations
This section has been translated automatically.

Mycobutin

Tables
This section has been translated automatically.

Major interactions of rifabutin

Quinidine	Quinidine effect ↓
Clarithromycin	Rifabutin toxicity (plasma levels around 80% ↑, possibly dose reduction).
Cotrimoxazole	Cotrimoxazole effect ↓
Coumarins	Coumarin effect ↓
Dapsone	Dapsone effect ↓
Didanosine	Palpitations, tachycardia
Fluconazole	Rifabutin levels around 80% ↑, possible dose adjustment.
Glucocorticoids	Glucocorticoid effect ↓
Cardiac glycosides	Cardiac glycoside effect ↓
Contraceptives, oral	contraceptive effect ↓
L-methadone	L-methadone effect ↓
Opioids	Opioid effect ↓
Phenytoin	Phenytoin effect ↓
Sulfonylureas	Sulfonylurea effect ↓