Retrograde ejaculation N50.88

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

"dry orgasm"

Definition
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Instead of the physiological antegrade ejaculation of the sperm from the urethra, there is a complete or partial retrograde ejaculation of the sperm into the bladder.

Etiopathogenesis
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Causes can be malformations, inflammations, tumours or surgical interventions on the bladder neck, more rarely also drugs (such as phenoxybenzamine e.g. dibenzyran and other alpha-sympatholytics e.g. Minipress) or diabetes mellitus.

Diagnosis
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Partially retrograde ejaculation results in reduced ejaculate volume (less than 2 ml), reduced sperm motility and greatly reduced ejaculate fructose values (significantly less than 120 mg/dl, partly not measurable); completely retrograde ejaculation results in absence of ejaculate despite orgasm; spermatozoa are then detected in the urine or urine sediment.

General therapy
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Exclusion of malformations, inflammations or tumours. Stop all drugs that can cause retrograde ejaculation.

Internal therapy
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In the case of infertility symphatikomimetics such as Midodrin (e.g. Gutron) 10-40 mg i.v. or Imipramine (e.g. Tofranil) 3 times 25 mg p.o. Good success with Ameziniummetilsulfat (e.g. Regulton) once/day 10 mg p.o. have been described (off-label use; evidence level IV). Cave! Sympathomimetic side effects, especially in older patients.

Literature
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  1. Ichiyanagi O et al (2003) Successful treatment of retrograde ejaculation with amezinium. Arch androl 49: 215-217
  2. Plewa GF (1989) The retrograde ejaculation - diagnosis and therapy. Dt Dermatol 37: 287-288
  3. Van der Linden PJ et al (1992) Retrograde ejaculation: successful treatment with artificial insemination Obstet Gynecol 79: 126-128

Incoming links (1)

Fructose in ejaculate;

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Last updated on: 29.10.2020