Raphecysts, median D29.4

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Apocrine cystadenoma of the penis; Median raphe cyst; Median raphecysts

Definition
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Smallest, embryonic, cystic malformations in mostly linear arrangement, which appear on the penis along the median raphe up to the anus.

Etiopathogenesis
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These cysts are thought to occur during embryonic development through abnormal folding or fusion of the paired urogenital/urethra folds. In men, the folds form the shaft of the penis and in women the labia minora.

Localization
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Ventral area of the penis, reaching along the median raphe to the anus, spreading forward to the glans.

Clinical features
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Smallest, 0.1-0.3 mm large, symptomless cysts in a linear arrangement.

Histology
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Epithelium-lined cyst without contact with the overlying epidermis, with partly single-layered epithelium, in sections also 1-4-layered high-prismatic epithelium.

Therapy
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Not necessary.

Literature
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  1. Acenero MJ, Garcia-Gonzalez J (2003) Median raphe cyst with ciliated cells: report of a case. On J Dermatopathol 25: 175-176
  2. Dini M et al (2001) Median raphe cyst of the penis: a report of two cases with immunohistochemical investigation. Am J Dermatopathol 23: 320-314
  3. Ohnishi T, Watanabe S (2001) Immunohistochemical analysis of human milk fat globulin 1 and cytokeratin expression in median raphe cyst of the penis. Clin Exp Dermatol 26: 88-92
  4. Ravasse P et al (2002) Perineal median raphe canal: a typical image. Urology 59: 136

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020