Raphecysts, median D29.4

Smallest, embryonic, cystic malformations in mostly linear arrangement, which appear on the penis along the median raphe up to the anus.

These cysts are thought to occur during embryonic development through abnormal folding or fusion of the paired urogenital/urethra folds. In men, the folds form the shaft of the penis and in women the labia minora.

Ventral area of the penis, reaching along the median raphe to the anus, spreading forward to the glans.

Smallest, 0.1-0.3 mm large, symptomless cysts in a linear arrangement.

Epithelium-lined cyst without contact with the overlying epidermis, with partly single-layered epithelium, in sections also 1-4-layered high-prismatic epithelium.

Not necessary.

1. Acenero MJ, Garcia-Gonzalez J (2003) Median raphe cyst with ciliated cells: report of a case. Am J Dermatopathol 25: 175-176.
2. Dini M et al (2001) Median raphe cyst of the penis: a report of two cases with immunohistochemical investigation. Am J Dermatopathol 23: 320-314

3. Jo J W (2019). Apocrine hidrocystoma on the penis: report of a case and review of previous cases. Annals of Dermatology, 31(4), 442. doi: 10.5021/ad.2019.31.4.442.

4. Ohnishi T, Watanabe S (2001) Immunohistochemical analysis of human milk fat globulin 1 and cytokeratin expression in median raphe cyst of the penis. Clin Exp Dermatol 26: 88-92
5. Ravasse P et al (2002) Perineal median raphe canal: a typical image. Urology 59: 136