Pyrimethamine
DefinitionThis section has been translated automatically.
Chemotherapy, antimalarials.
Half-lifeThis section has been translated automatically.
> 4 days
Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of dihydrofolate reductase.
Spectrum of actionThis section has been translated automatically.
In combination with sulfones or sulfonamides effective against all human pathogenic Plasmodium spp., as single agent against Toxoplasma gondii.
IndicationThis section has been translated automatically.
In combination preparations for malaria tertiana. Therapy of toxoplasmosis including ocular and congenital manifestations and immunodeficiency.
Limited indicationThis section has been translated automatically.
Pregnancy, folic acid deficiency, liver dysfunction, megaloblastic anemia, renal insufficiency.
Dosage and method of useThis section has been translated automatically.
- Curative malaria therapy (malaria without complications): Application in combination with sulfadoxin (combination preparation: Fansidar contains 500 mg pyrimethamine and 25 mg sulfadoxin): 1500 mg pyrimethamine/75 mg sulfadoxin p.o. as 1-day therapy. Dose reduction for children and adults < 45 kg bw.
- Toxoplasmosis (in combination with 4 g sulfadiazin/day p.o.): adults and children > 6 years: 100 mg/day for 3 weeks in combination with folic acid 100 mg/day.
- Toxoplasmosis encephalitis in AIDS: 100 mg/day in combination with sulfadiazine and folic acid, followed by recurrent prophylaxis at 50 mg/day.
Remember! Before therapy determination of glucose-6-phosphate dehydrogenase.
Undesirable effectsThis section has been translated automatically.
Blood count changes, allergic reactions, headaches, heart rhythm disturbances, gastrointestinal complaints, insomnia, dry mouth, shock.
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
Severe hematopoiesis, lactation.
PreparationsThis section has been translated automatically.
Daraprim; Fansidar (combination with sulfadoxine)
TablesThis section has been translated automatically.
Significant interactions of pyrimethamine
Dapson |
Haematotoxicity ↑ |
Sulfonamides |
Haematotoxicity ↑ |
Trimethoprim |
Haematotoxicity ↑ |
Zidovudine |
Zidovudine toxicity ↑ |
Cytostatics |
Haematotoxicity ↑ |
Anticoagulants |
Enhanced impact |