Folinic acid
Synonym(s)
Calcium folinate; disodium salt; Folinic acid; Sodium folinate
DefinitionThis section has been translated automatically.
Metabolically active form of folic acid (vitamin from the vitamin B complex).
IndicationThis section has been translated automatically.
Substitution therapy in patients undergoing methotrexate or cotrimoxazole therapy with pronounced megalocytic anaemia (folic acid has no effect in this indication because the enzymes that convert folic acid into the metabolically active form of folinic acid are inhibited).
Dosage and method of useThis section has been translated automatically.
- For folic acid deficiency: 5- max. 15 mg/day p.o. or i.v.
- As a comedication in methotrexate therapy, see below Table 1.
Undesirable effectsThis section has been translated automatically.
Allergic reactions, bronchospasm, dyspnoea, CNS disorders, gastrointestinal disorders.
InteractionsThis section has been translated automatically.
See Table 2.
ContraindicationThis section has been translated automatically.
Megaloblastic anemia due to isolated vitamin B12 deficiency.
PreparationsThis section has been translated automatically.
Leucovorin (folic acid), Oncofolic, Vorina
Note(s)This section has been translated automatically.
S.a. Methotrexate regarding the simultaneous administration of folic acid during MTX therapy.
LiteratureThis section has been translated automatically.
- Weatherhead SC et al (2007) An open-label, dose-ranging study of methotrexate for moderate-to-severe adult atopic eczema. Br J Dermatol 156: 346-351
TablesThis section has been translated automatically.
Dosage of folinic acid as a function of MTX level
Methotrexate serum levels [M] |
Folinic acid per 6 hours [mg] |
5 x 10-5 |
20 |
1 x 10-6 |
100 |
2 x 10-6 |
200 |
> 2 x 10-6 |
proportional rise |
Interactions of folinic acid
Fluorouracil |
Fluorouracil effect ↑ |
Methotrexate |
MTX Effect ↓ |
Primidone |
Folinic acid levels ↓ |
Pyrimethamine |
Pyrimethamine effect ↓ |