Purpura thrombocytopenic M31.1; M69.61(Thrombozytopenie)

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch


Purpura in thrombocytopenia; Thrombocytopenic purpura

This section has been translated automatically.

Polyätiological, microangiopathic, mostly small spotted purpura (petechiae) caused by thrombocytopenia of varying aetiology and severity.

This section has been translated automatically.

The causes of thrombocytopenia include:

  • educational disorders:
    • Diminished megakaryocytopoiesis:
      • Congenital
      • Acquired: E.g. by drugs, radiotherapy, chemicals, viruses, bacterial infections.
      • Displacement: E.g. by bone marrow carcinosis, leukemia, malignant lymphomas (e.g. plasmocytoma), osteomyelofibrosis.
    • Ineffective thrombocytopoiesis: e.g. Wiskott-Aldrich syndrome.
  • Increased degradation or consumption:
    • Immunological:
      • Primary autoantibody formation: e.g. idiopathic thrombocytopenic purpura.
      • Secondary autoantibody production: e.g. drugs, collagenosis, immune complex diseases, antiphospholipid antibody syndrome).
    • Non-immunological:
      • E.g. disseminated intravascular coagulation.
  • distribution disorders:
    • E.g. platelet pooling in the spleen for splenomegaly.

Clinical features
This section has been translated automatically.

The clinical picture of thombopenic purpura (platelet count <140,000/ul) is characterized by orthostatic, blurred, (fine spotted - non-paplpable) petechial haemorrhages (bleeding: check by diascopy - easy to perform by firm thumb compression of the skin). Capillary damage is also common. Recurrent orthostatic petechial haemorrhages lead to pigmentation of the skin by haemosiderin deposits.

With advanced thrombocytopenia, there may be extensive bleeding over the entire surface of the egin. Linear patterns in scratch marks (Purpura facctitia) are also possible. In these cases, clarification of an existing coagulation disorder is always required.

Often thrombocytopenia is not known, as there is usually no danger of bleeding as long as the number of functional thrombocytes is > 30,000 per ul and plasmatic coagulation is normal.

This section has been translated automatically.

  • Varies depending on the triggering cause.
  • Avoid a triggering drug. Depending on the clinic and platelet count, systemic glucocorticoids are indicated, e.g. prednisone (e.g. Decortin) initial 100 mg/day, gradual reduction according to clinic.
  • The treatment of thrombocytopenia is a treatment to be carried out under internal control.

This section has been translated automatically.

The thrombocytopenic purpura should not be confused with the Moschcowitz syndrome, the thrombotic thrombocytopenic purpura.


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Add section

Last updated on: 29.10.2020