Synonym(s)
protein tyrosine phosphatase; SHP-2
DefinitionThis section has been translated automatically.
PTPN11 is the acronym for "protein tyrosine phosphatase non-receptor type 11", also known as "protein tyrosine phosphatase 1D" -PTP-1D-, an enzyme encoded by the PTPN11 gene in humans.
PTPN11 is amember of the protein tyrosine phosphatase (PTP) family that is found in many tissues. This family of enzymes consists of signal molecules that regulate a variety of cellular processes including cell growth, cell differentiation and oncogenic transformations.
Mutations of the PTPN11 gene are responsible for Noonan Syndrome.
They are also found in acute myeloid leukemia. Oncogenic mutations of the PTPN11 gene are also found in acrolentiginous melanoma.
Prof. Dr. med. Peter Altmeyer