Pseudotumour of cutaneous inflammatory D48.5

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 03.12.2022

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Synonym(s)

cutaneous inflammatory pseudotumor; inflammatory myofibroblastic tumor; plasma cell granuloma; Plasma cell granuloma

History
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Bahadori and Liebow 1973; first description in Haut: Hurt and Santa Cruz 1990;

Definition
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Very rare (only a few cases have been described worldwide), mostly extracutaneous (lung, spleen, lymph nodes) localized, benign, plasma cell-rich (also plasma cell granuloma) pseudolymphoma.

Etiopathogenesis
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Unknown. Discussed are exclusively inflammatory genesis and infectious causes, e.g. EBV infection.

Localization
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Especially lungs, spleen, lymph nodes, skin (rarely) are affected.

Clinical features
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Clinically typical is a solitary, asymptomatic, red-brown plaque or a corresponding lump with a smooth surface. Rare is a multiple occurrence.

Histology
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Dermal nodular infiltrate with lymphocytes, numerous plasma cells and reactive germinal centers (here expression of CD20; CD79a). Isolated eosinophilic and neutrophilic granulocytes. Tendency to fibrosis.

Immunohistology: Polyclonality of the infiltrate.

Differential diagnosis
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Plasmocytoma, MALT-type extranodal B-cell lymphoma.

Therapy
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Excision is the treatment of choice.

Literature
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  1. Bahadori M, Liebow AA (1973) Plasma cell granulomas of the lung. Cancer 31: 191-208
  2. Buccoliero AM (2003) Plasma cell granuloma--an enigmatic lesion: description of an extensive intracranial case and review of the literature. Arch Pathol Lab Med 127: e220-223
  3. Hurt MA, Santa Cruz D (1990) Cutaneous inflammatory pseudotumor. Lesions resembling "inflammatory pseudotumors" or plasma cell granulomas" of extracutaneous sites. At the castle catholic 14: 764-773
  4. Ide F (2000) Plasma cell granuloma of the oral mucosa with angiokeratomatous features: a possible analogue of cutaneous angioplasmocellular hyperplasia. Oral Surg Oral Med Oral Med Oral Pathol Oral Radiol Endod 89: 204-207
  5. Nakajima T (2001) Cutaneous inflammatory pseudotumor (plasma cell granuloma). Br J Dermatol 144: 1271-1273
  6. Nonaka D et al (2005) So-called inflammatory myofibroblastic tumour: a proliferative lesion of fibroblastic reticulum cells? Histopathology 46: 604-6013
  7. Young M (1993) Cutaneous inflammatory pseudotumor: A case report with immunohistochemical and ultrastructural studies. Pathology 25: 405-409

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Last updated on: 03.12.2022