Proton pump inhibitors
Synonym(s)
Proton pump inhibitors
Definition
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Drugs that lead to a reduction in the formation of gastric acid by inhibiting the proton pump in the stomach.
Indication
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In dermatology, proton pump inhibitors are used particularly in patients with metastatic malignant melanoma with metastasis in the area of the GIT as well as in patients with Lyell syndrome, burns or severe erythema exsudativum multiforme ( Stevens-Johnson syndrome) for the prophylaxis of stress ulcers (see Table 1).
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Limited indication
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Pregnancy, lactation, liver dysfunction, kidney failure.
Undesirable effects
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- Cutaneous side effects: Rare (0.3-1% of patients) urticaria, eczema, contact dermatitis, allergic, other allergic reactions.
- Cutaneous side effects: headache, visual disturbances, haematopoietic disturbances, thrombocytopenia, eosinophilia, gastrointestinal disturbances, impotence, amenorrhea, proteinuria.
Interactions
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See Table 2.
Contraindication
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Children and adolescents < 16 years, severe liver dysfunction.
Tables
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Overview of the most important proton pump inhibitors and their dosage
Substance |
Dosage |
Preparation |
Lansoprazole |
30-60 mg/day p.o. |
Agopton, Lanzor |
Omeprazole |
20-40 mg/day p.o. or 10-20 mg/day i.v. |
Antra MUPS, Antra pro infusione, Ome TAD, Ome-Q |
Pantoprazole |
40-80 mg/day p.o. |
Pantozole |
Rabeprazole |
10-20 mg p.o. |
Pariet |
Essential interactions of proton pump inhibitors
Barbiturates |
Barbiturate levels ↑ |
Contraceptives, oral |
Contraception impaired, additional anticonceptive measures required |
Laxatives |
mutual effect ↑ |
Phenytoin |
Phenytoin levels ↑ |
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Prof. Dr. med. Peter Altmeyer