Synonym(s)
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Rare, malignant, infiltrating sweat gland tumor originating from the intraepidermal part of the eccrine sweat gland excretory duct. Retrograde ingrowth into the epidermis is characteristic.
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Slow-growing, plate-like or nodular tumors with ulcerations. In terms of appearance, size and localization, the tumors are highly variable. Frequently, they arise on the floor of a poroma that has existed for years. Clinical malignancy criterion is a sudden rapid growth of the preexisting tumor. Porocarcinomas may also develop in a nevus sebaceus.
Lymphogenic metastasis is possible (12% of cases), as is seeding of epidermotropic metastases. Rarely, visceral metastases develop.
HistologyThis section has been translated automatically.
Often arising at the base of a poroma, asymmetric carcinoma that broadly infiltrates the deeper portions of the dermis (and subcutis). Tumor formations with reticularly branched, ribbon-like structures that make broad-based contact with the surface epithelium are characteristic. As in poroma, the formation of ductal as well as light cell structures is possible. Cell formations of small basaloid cells with chromatin-rich nuclei are seen. Abundant mitoses. Evidence of mass necrosis (see also under poroma).
The intraepithelial form of porocarcinoma is called malignant hidroacanthoma simplex. It is characterized by poroid epithelial clusters with densely packed tumor cells, numerous mitoses, and a markedly increased proliferation rate.
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LiteratureThis section has been translated automatically.
- Gartmann H (1985) Eccrine porocarcinoma. Z Hautkr 60: 555-562
- Grayson W et al (2003) Eccrine porocarcinoma of the penis. J Urol 169: 611-612
- Gu LH et al (2003) Aberrant expression of p16 and RB protein in eccrine porocarcinoma. J Cutan cathode 29: 473-479
- Helmer A et al (2006) Eccrine porocarcinoma in addition to multiple other epithelial skin tumors. Dermatologist 57: 1120-1121
- Horn T et al (1985) Malignant eccrine poroma. Z Hautkr 60: 992-999
- Johr R et al (2003) Eccrine porocarcinoma arising in a seborrheic keratosis evaluated with dermoscopy and treated with Mohs' technique. Int J Dermatol 42: 653-657
- Murphy LA; Barlow RJ (2003) Eccrine porocarcinoma treated with Moh`s micrographic surgery: a report of three cases. Br J Dermatol 149 (Suppl 64): 103
- Pinkus H, Mehregan AH (1963) Epidermotrophic eccrine carcinoma: a case combining features of eccrine poroma and Paget's dermatosis. Arch Dermatol 88: 597-606
- Shaw M et al (1982) Malignant eccrine poroma: a study of twenty-seven cases. Br J Dermatol 107: 675-680
- Snow SN et al (1992) Eccrine porocarcinoma of the face. J Am Acad Dermatol 27: 306-311
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Incoming links (8)
Carcinoma eccrine epidermotropic; Carcinoma epidermotropic eccrine; Hidroacanthoma simplex maligna; Malignant Hidroacanthoma simplex; Poroepithelioma, eccrine; Poroma, dysplastic; Poroma, malignant eccrines; Syringoacanthoma, malignant;Outgoing links (10)
Cutaneous non hodgkin lymphomas; Excision; Hidroacanthoma simplex; Inverted follicular keratosis; Keratosis seborrhoeic (overview); Melanoma amelanotic; Merkel cell carcinoma; Microscopically controlled surgery; Nevus sebaceus; Squamous cell carcinoma of the skin;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer