Synonym(s)
Acetylgalactosaminyltransferase; CAS number: 9075-15-4; GalNacT; glycoprotein acetylgalactosaminyltransferase; N-acetylgalactosaminyltransferase; Polypeptide-N-acetylgalactosamine transferase; protein UDP acetylgalactosaminyltransferase; UDP-acetylgalactosamine-glycoprotein; UDP-GalNAc:polypeptides N-acetylgalactosaminyltransferase; UDP-GalNAc:polypeptides N-acetylgalactosaminyl transferase; UDP-N-acetyl-alpha-D-galactosamines:polypeptides; UDP-N-acetyl-D-galactosamine:polypeptides N-acetylgalactosaminyl-transferase; UDP-N-acetylgalactosamine-glycoprotein, UDP-N-acetylgalactosamine:polypeptides; UDP-N-acetylgalactosamine:kappa-casein polypeptides; Uridine diphosphoacetylgalactosamine glycoprotein
DefinitionThis section has been translated automatically.
The polypeptide N-acetylgalactosaminyltransferase, also abbreviated as GalNac-T, is an enzyme that catalyses the chemical reaction UDP-N-acetyl-D-galactosamine + polypeptides = UDP + N-acetyl-D-galactosaminyl polypeptides. The enzyme belongs to the family of glycosyltransferases, especially the hexosyltransferases. It requires as cofactors: magnesium and calcium.
The substrates of the polypeptides N-acetylgalactosaminyltransferase are UDP-N-acetyl-D-galactosamines and polypeptides; its two reaction products are UDP and N-acetyl-D-galactosaminyl polypeptides. GalNacT is expressed in normal brain tissue and in a number of malignancies, including colon and gastric cancer, adult T-cell leukemia cells and neuroblastoma.
LiteratureThis section has been translated automatically.
- Gaiser MR et al (2018) Liquid biopsy to monitor melanoma patients. J Dtsch Dermatol Ges 16:405-414.
- Sugiura M, Kawasaki T, Yamashina I (1982). "Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66 J. Biol. Chem. 257 (16): 9501-7.
Prof. Dr. med. Peter Altmeyer