Plummer-vinson syndrome D50.11

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 01.07.2022

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Synonym(s)

Dysphagia sideropenic; Iron deficiency dysphagia; Kelly-Paterson syndrome; Kelly-Paterson Syndrome; Paterson-Kelly Syndrome; Sideropenic Dysphagia

History
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Plummer, 1912; Kelly, 1919; Paterson, 1919; Vinson, 1919

Definition
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Dysphagia in mucosal atrophy of the mouth, pharynx, and esophagus with iron deficiency anemia.

Etiopathogenesis
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Iron deficiency (due to various diseases, the demand is increased or the absorption is decreased). A complex vitamin deficiency is also discussed.

Clinical features
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Skin changes: Seborrheic eczema on the face, hyperkeratosis on the rest of the integument. Nail dystrophy and brittle hair, rhagades of the corner of the mouth, glossitis superficialis, tongue burning, atrophic mucous membrane changes in the mouth, throat and oesophagus.

Therapy
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Iron substitution (e.g. Ferro sanol duodenal) 2(-3)times 50 mg/day, later 2(-3)times 100 mg/day for 3 months. Check Hb and reticulocytes after 1 week. Parenteral substitution only if peroral therapy is not possible, then slowly inject 20-40 mg iron-III (e.g. Ferrlecit). Caution. Do not administer vitamin C therapy at the same time!

Literature
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  1. Atmatzidis K et al (2003) Plummer-Vinson syndrome. Dis esophagus 16: 154-157
  2. Kelly AB (1919) Spasm at the entrance of the esophagus. J Laryngology Rhinology Otology (London) 34: 285-289
  3. Paterson DR (1919) A clinical type of dysphagia. J Laryngology Rhinology Otology (London) 34: 289-291
  4. Plummer HS (1912) Diffuse dilatation of the esophagus without anatomic stenosis (cardiospasm). A report of ninety-one cases. J Am Med Assoc (Chicago) 58: 2013-2015
  5. Vinson PP (1919) A case of cardiospasm with dilatation and angulation of the esophagus. Med Clinics North America (Philadelphia) 3: 623-627

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 01.07.2022