Plexiform fibrohistiocytic tumor

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Plexiform fibrohistiocytic tumor

History
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Enzinger and Zhang 1988

Definition
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Preferably in children and young adults, fibro-myofibroblastically differentiated, slowly but locally aggressively growing, rarely metastatic, cutaneously-subcutaneously localized, painless tumor.

Manifestation
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Children and young adults, also appearing at a later age.

Histology
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Tumor parenchyma arranged in baths and fascicles from fibroblastically or myofibroblastically differentiated spindle cell formations. Interspersed are epithelioid or histiocytic cells with multinucleated giant cells. Mitoses are rare. Also myxoid or fibrous sections. The tumor cells are immunoreactive for vimentin, CD68; negative for S-100 protein and pancytokeratin.

Therapy
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Excision with sufficient safety distance (danger of recurrence).

Literature
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  1. Elwood H et al (2011) Dermal and Subcutaneous Plexiform Soft Tissue Neoplasms. Surg Pathol Clin 4: 819-842.
  2. Harrill JC et al (2014) Plexiform fibrohistiocytic tumor of the foot: a case report. J Foot Ankle Surgery 53:635-637.
  3. Jacobson-Dunlop E et al (2011) Features of plexiform fibrohistiocytic tumor in skin punch biopsies: a retrospective study of 6 cases. At J Dermatopathol 33:551-556.
  4. Pissoat L et al (2011) Plexiform fibrohistiocytic tumor. Dermatologist 62: 809-812.
  5. Yalcinkaya U et al. (2013) Plexiform fibrohistiocytic tumor of bone. Pathol Int 63: 554-558.

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Last updated on: 29.10.2020