Hierfür ist eine Anmeldung erforderlich. Bitte registrieren Sie sich bei uns oder melden Sie sich mit Ihren Zugangsdaten an.
Pentostatin
Definition
This section has been translated automatically.
Cytostatic, antimetabolite, purine antagonist.
Pharmacodynamics (Effect)
This section has been translated automatically.
Irreversible catalysis of the deamination from adenosine to inosine and from deoxyadenosine to deoxyinosine. Disruption of DNA synthesis, induction of apoptosis.
You might also be interested in
Indication
This section has been translated automatically.
Hair cell leukemia, B-cell type CLL, prolymphocytic leukemia, cutaneous T-cell lymphomas.
Dosage and method of use
This section has been translated automatically.
4 mg/m2 KO/day i.v. as a bolus every 2 weeks
Notice!
Before administration intravenous fluid substitution of 500-1000 ml!
Undesirable effects
This section has been translated automatically.
Myelosuppression, nausea, allergic reactions, fever, fatigue, headaches, liver and kidney dysfunction.
Interactions
This section has been translated automatically.
Myelotoxic substances.
Contraindication
This section has been translated automatically.
Pregnancy, lactation, children < 16 years.
Preparations
This section has been translated automatically.
Nipent
.jpg){kind=small}
Prof. Dr. med. Peter Altmeyer