Pemphigus vegetans, type neumann L10.1

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Erythema bullosum vegetans; Neumann's disease

History
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Neumann, 1886

Definition
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Pemphigus vegetans with initially limp, whitish vesicles.

Localization
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Intertriginous spaces: lip commissures, nasolabial folds, vulva and anal area, axillary and inguinal.

Clinical features
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Flaccid, rapidly tearing blisters. Development of papillomatous growths on the resulting erosions. Epithelial remnants in the marginal area. Verrucous and hyperkeratotic transformation of the lesions. Reducing with reddish-brown pigmentation.

Histology
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Suprabasal bladder, acantholysis, acanthosis, papillomatosis, intraepidermal microabscesses from eosinophilic leukocytes.

Therapy
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Literature
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  1. Downie JB et al (1998) Pemphigus vegetans-Neumann variant associated with intranasal heroin abuse. J Am Acad Dermatol 39: 872-875
  2. Jansen T et al (2001) Pemphigus vegetans. A historical perspective. dermatologist 52: 504-509
  3. Near H (1993) Neumann type pemphigus vegetans with fatal outcome. dermatologist 44: 99-102
  4. Neumann I (1886) About Pemphigus vegetans (frambosioides). Quarterly Journal for Dermatology and Syphilis (Vienna) 13: 157-178

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020