Pemphigoid antibodies

Synonym(s)

Basement membrane antibody

Definition
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Antibodies directed against components of the basement membrane, which can be detected by direct immunofluorescence (DIF) in tissue or indirect immunofluorescence (IIF) in serum of patients. The detection of these antibodies (mainly antibodies of the IgG class) is diagnostically groundbreaking in pemphigoid class diseases.

Occurrence
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Detectable in about 70% of all patients with bullous pemphigoid, see Table 1.

Tables
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Disease	Target antigen	Morphological structure	Molecular weight [kDa]
Bullous pemphigoid	BP 180/ BPAG2	Hemidesmosomes/anchoring fibrils	180
Bullous pemphigoid	BP 230/ BPAG1	Hemidesmosomes	230
Pemphigoid gestationes	BP 180/ BPAG2	Hemidesmosomes/anchoring fibrils	180
Pemphigoid gestationes	BP 230/ BPAG1	Hemidesmosomes	23
Cicatrizing pemphigoid	BP 180/ BPAG2	Hemidesmosomes/anchoring fibrils	180
	BP 230/ BPAG1	Hemidesmosomes	230
	laminin 5	anchoring fibrils	105, 140, 165
	laminin 6	anchoring fibrils/extracellular matrix	165, 200, 220
	Integrin ß 4 subunit	Hemidesmosomes	200
IgA linear dermatosis	LAD-1/ LABD97	anchoring filaments	97/120
	BP 180/ BPAG2	Hemidesmosomes/anchoring filaments	180
	BP230/ BPAG1	Hemidesmosomes	230
	Type VII collagen	anchoring filaments	145/290
Anti-p200 pemphigoid	p 200	Adhesion molecule of basement membrane?	200
Epidermolysis bullosa acquisita	Type VII collagen	anchoring filaments	145/290
Bullous systemic lupus erythematosus	Type VII collagen	anchoring filaments	145/290