Pasi

Synonym(s)

Psoriasis Area and Severity Index

History
This section has been translated automatically.

Fredriksson and Petterson, 1978

Definition
This section has been translated automatically.

Best-known, well-standardized index scale (scoring system) for diagnosing and determining the severity of psoriasis. Frequently used in clinical practice for documentation of admission findings and discharge findings in psoriatic patients as well as for endpoint control in clinical trials or pivotal studies.

Important classification for therapy decision systemic or local therapy.

Severity classification of psoriasis - from the current German S 3- guideline (https://www.awmf.org/uploads/tx_szleitlinien/013-001l_S3_Therapie-Psoriasis-vulgaris_2021-07.pdf)

Mild: moderate-severe:

PASI <= 10 and PASI > 10

BSA <= 10 and BSA > 10

DLQI <= 10 DLQI > 10

An upgrade of the mild form according to PASI calculation may result from infestation of sensitive areas (scalp, ano-genital region, nail infestation) or resistance to therapy.

Other PASI values: PASI 75 is a dynamic parameter used for therapy control of systemic therapy in psoriasis. It describes the percentage improvement of the PASI index, i.e. a 75% reduction of the PASI index compared to the baseline value.

Corresponding to PASI 90 or PASI 100.

You might also be interested in

Advertisment

Dermatology

Onchocerciasis

Chronic form of filariasis (river blindness) caused by Onchocerca volvulus. The worm larvae are transmitted...

General information
This section has been translated automatically.

Originally the PASI was developed as a target for efficacy studies of retinoids in patients with chronic plaque psoriasis. In recent years, the method has become the gold standard for targets in clinical studies on psoriasis.

The aim of the PASI is to document the area and severity of skin lesions. The PASI consists of an area and a dermatological component.
The affected area (A) is determined separately for head, trunk, upper and lower extremities. A numerical scale is used (0 = no involvement, 1 = < 10%, 2 = 10 to < 30%, 3 = 30 to < 50%, 4 = 50 to < 70%, 5 = 70 to < 90% and 6 = 90-100%).
In the dermatological part, erythema (E = erythema), infiltration (I = infiltration) and desquamation (D = desquamation) are assessed on a scale of 0 to 4. The head (K = head; h = head) is weighted with 0.1, the trunk (R = trunk; t = trunc) with 0.3, the upper extremity (A = arms; u = upper limb) with 0.2 and the lower extremity (B = legs; l = lower limb) with 0.4.

Scheme for determining the PASI
The PASI can take values from 0 to 72 and is calculated as follows:
Calculation of the indices for the individual body sections	K = 0,1 x (EK + IK + DK) x AK
	A = 0,2 x (EA + IA + DA) x AA
	R = 0.3 x (ER + IR + DR) x AR
	B = 0.4 x (EB + IB + DB) x AB

PASI = K + A + R + B	0,1 x (EK + IK + DK) x AK
	+ 0,2 x (EA + IA + DA) x AA
	+ 0.3 x (ER + IR + DR) x AR
	+ 0,4 x (EB + IB + DB) x AB

Repeated determination of the PASI or the indices of the individual body sections can be used for the documentation of the intra-individual course of disease as well as for the comparison with other patients.

Note(s)
This section has been translated automatically.

Remember! The application of the PASI-Score has found a wide spread use in in-patient treatment and also in out-patient treatment. Decisive for its application under outpatient conditions was, apart from the documentation of the therapy success, above all the definition of the proof of medium to severe psoriasis for the balneo-phototherapy to be carried out on an outpatient basis, as determined by the Federal Joint Committee. For the billing of the balneo-phototherapy (bath-PUVA-therapy or photo brine-therapy) a PASI-Score > 10 has to be proved here.

Literature
This section has been translated automatically.

Feldman SR et al (1996) The self-administered psoriasis area and severity index is valid and reliable. J Invest Dermatol 106: 183-186
Fredriksson T, Petterson U (1978) Severe psoriasis-oral therapy with a new retinoid. Dermatologica 157: 238-244
Sampogna F et al (2003) Performance of the self-administered psoriasis area and severity index in evaluating clinical and sociodemographic subgroups of patients with psoriasis. Arch Dermatol 139: 353-358
Shikiar R et al. (2003) Validity and reliability of patient reported outcomes used in psoriasis: results from two randomized clinical trials. Health and Quality of Life Outcomes 1: 53
https://www.awmf.org/uploads/tx_szleitlinien/013-001l_S3_Therapie-Psoriasis-vulgaris_2021-07.pdf

Tables
This section has been translated automatically.

Scheme for determining the psoriasis area and severity index (PASI score)

Name of the patient:
Date of birth:												Date of diagnosis:

Severity of the psoriatic lesions
Please circle the appropriate numerical value for each of the following efflorescences and localizations according to the degree of expression! Degree of efflorescence: (0 = no efflorescence or no infestation; 1 = mild infestation; 2 = moderate infestation; 3 = severe infestation; 4 = very severe infestation)
		Localization
Line number	Efflorescence	Head					Fuselage						Arms					Legs
		state of expression					state of expression						state of expression					state of expression
1	Erythema	0	1	2	3	4	0	1	2	3	4		0	1	2	3	4	0	1	2	3	4
2	Infiltration	0	1	2	3	4	0	1	2	4	4		0	1	2	3	4	0	1	2	3	4
3	Scaling	0	1	2	3	4	0	1	2	3	4		0	1	2	3	4	0	1	2	3	4
4	Total

Infestation of the body surface
Please note the area infested in line 6 for the respective localisations. Circle the appropriate numbers before the percentages corresponding to the infested area. Infested body surface: (0 = no infestation; 1 = < 10% infected area at the location; 2 = 10-29% infected area at the location; 3 = 30-49% infected area at the location; 4 = 50-69% infected area at the location; 5 = 70-89% infected area at the location; 6 = 90-100% infected area at the location)
Line number		Localization
5			Head						Fuselage						Arms					Legs
			infested area						infested area						infested area					infestedarea
6	Infested area		0	no head injury					0	no infestation of the fuselage					0	no infestation of the arms				0	no infestation of the legs
			1	< 10% infested					1	< 10% infested					1	< 10% infestation				1	< 10% infested
			2	10-29% infested					2	10-29% infested					2	10-29% infested				2	10-29% infested
			3	30-49% infested					3	30-49% infested					3	30-49% infested				3	30-49% infested
			4	50-69% infested					4	50-69% infested					4	50-69% infested				4	50-69% infested
			5	70-89% infested					5	70-89% infested					5	70-89% infested				5	70-89% infested
			6	90-100% infested					6	90-100% infested					6	90-100% infested				6	90-100% infested
7	Product of lines 4 + 6
8	Factors of the basket surface		x 0,10						x 0,30						x 0,20					x 0,40
9	Product of lines 7 + 8
10	PASI-Score = sum of line 9