DefinitionThis section has been translated automatically.
A substance that is closely related to clozapine in terms of structure and chemistry. In contrast to clozapine, it can cause extrapyramidal motor disorders (EPMS), especially at high doses. However, the risk of agranulocytosis is lower with olanzapine than with clozapine.
IndicationThis section has been translated automatically.
Olanzapine is approved for the treatment of schizophrenia and bipolar disorder when a manic phase has responded to treatment. Dermatologically, good effects have been demonstrated in dermatozoic mania.
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Dosage and method of useThis section has been translated automatically.
The average dose is 5-20 mg/day. In order to avoid adverse side effects, a creeping dosage of initially 5 mg daily is recommended.
InteractionsThis section has been translated automatically.
The simultaneous administration of olanzapine and other drugs that prolong the QT interval in the ECG must be avoided. Drugs that lower the seizure threshold should not be used at the same time or should only be used with great caution, as olanzapine also promotes epileptic seizures.
ContraindicationThis section has been translated automatically.
Narrow-angle glaucoma; psychotic states in elderly dementia patients.
PreparationsThis section has been translated automatically.
Cyprus
Note(s)This section has been translated automatically.
Compliance with olanzapine treatment is often affected by significant weight gain and drowsiness. Clozapine and olanzapine are thought to cause weight gain, which is more common than with other neuroleptics, by interfering with the action of insulin so that carbohydrate metabolism is impaired. This could also explain the increased risk of diabetes manifestation when olanzapine is treated.
LiteratureThis section has been translated automatically.
- Meehan WJ et al (2006) Successful treatment of delusions of parasitosis with olanzapine. Arch Dermatol 142: 352-354
Prof. Dr. med. Peter Altmeyer