Ointments hydrophobic

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 16.02.2021

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Hydrocarbon gels; Hydrophobic ointments; Wax Ointment (DAB)

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Water-free bases that can only absorb small amounts of water. These include:

  • Hydrocarbon gels: e.g. Vaselinum album and Vaselinum flavum, paraffins (Paraffinum solidum and microcristallinum), liquid paraffins (Paraffinum subliquidum and perliquidum)
  • Lipogels (particularly well tolerated due to their strong skin affinity), in contrast to hydrocarbon gels, must be stabilized with the help of antioxidants (note: vegetable oils contain tocopherols as antioxidants). Examples: vegetable oils or animal fats, synthetic glycerides, waxes (cera alba, cera flava, cera liquida, cetyl palmitate, cetyl alcohol), liquid polyalkylsiloxanes (= silicone oils, e.g. dimethicone).

Pharmacodynamics (Effect)
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Moisture-impermeable covering of treated skin areas with maceration of the stratum corneum and penetration of contained medicinal substances even into deeper skin layers.

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Without the addition of emulsifiers, processing in water or aqueous drug solutions is not possible or only possible to a very limited extent, mixing with hydrophilic bases (e.g. hydrogels, O/W emulsions) is also only possible to a limited extent. Peroxides (protection against light, air and heat) can cause oxidative changes in incorporated active ingredients.

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Examples of ready-to-use preparations: Ash Base Fatty Ointment, Dermatop Base Fatty Ointment, Excipial Almond Oil Ointment, Neribas Fatty Ointment, Kerasal Base Ointment, Topisolon Base Fatty Ointment.


Last updated on: 16.02.2021