Non-biologic immunsuppressove drug for inflammatory skin diseases

Non-biological immunosuppressants/modulators such as azathioprine, dapsone, methotrexate or ciclosporin are basic treatment options for a variety of autoimmune diseases and chronic inflammatory skin diseases. Some of these drugs were originally used to treat malignant tumors (e.g. azathioprine or methotrexate) or infectious diseases (e.g. hydroxychloroquine or dapsone), but are now mainly used for their immunosuppressive/immunomodulatory effects.

• Purine synthesis inhibitors
  • azathioprine
    
• Folic acid synthesis inhibitors
  • methotrexate
• Antimalarials
  • Hydroxychloroquine
• Alkylants
  • Cyclophosphamide
• Pyrimidine synthesis inhibitors
  • Leflunomide (dihydroorotate dehydrogenase inhibitor)
• Glucocorticosteroids
• Other drugs
  • Dapsone (inhibits dihydrofolic acid)
  • Ciclosporin
  • Mycophenolate mofetil
  • Fumarates