Nikolsky phenomenon i

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 17.09.2026

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Synonym(s)

Nikolsky Phenomenon

History
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The name is derived from the Russian dermatologist Pyotr Vasilievich Nikolski (1858–1940). 

Definition
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The ability to peel off clinically healthy-appearing skin adjacent to skin lesions when firm, lateral pressure is applied. This phenomenon is not specific to any particular skin disease. It can be elicited, for example, in pemphigus vulgaris, exfoliative dermatitis of the newborn (= staphylococcal scalded skin syndrome), lichen planus pemphigoides, Lyell’s syndrome or Stevens-Johnson syndrome, as well as in cases of scalding (see also Nikolski phenomenon II).  

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Last updated on: 17.09.2026