Mycosis fungoid tumor stage C84.0

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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mycosis fungoides tumor-stage; Mycosis fungoid tumor stage

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Most common (about 50% of all CTCL), chronic progressive, phased, primarily cutaneous T-cell lymphoma (indolent, low malignant T-cell lymphoma), which originates from CD4-positive, small to medium-sized T-cells (T-helper lymphocytes).

Clinical features
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  • tumor stage ("tumor stage"):
  • Combination pattern of large red patches, red scaly plaques and formation of nodules in lesional skin; these have a strong tendency to ulceration.
    • Increasing severe itching, especially in affected skin.
    • Non-specific and specific lymph node infestation (biopsy necessary).
    • The involvement of internal organs increases with increasing tumor load.
    • Increasing significant disturbance of the general condition.
    • Tendency to septic bacterial and viral infections.
  • Accompanying symptoms of mycosis fungoides:
    • Mucosal involvement: Possible in every phase; especially of the oral mucosa, tongue, tonsils, nasal cavities, pharynx.
    • Organ involvement: Involvement of the spleen, liver, lungs, gastrointestinal tract or CNS in very late stages of the tumour. Skeletal involvement missing.

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Clinical data of further illustrations and therapy see below Mycosis fungoides (overview).

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  1. Bosisio FM et al (2015) Expression of T-follicular helper markers in sequential biopsies of progressive mycosis fungoides and other primary cutaneous T-cell lymphomas. At J Dermatopathol 37:115-121
  2. Hodak E et al (2014) Response to: "Tumor stage mycosis fungoides in nonblood-related family members". J Am Acad Dermatol 71:1002-1003
  3. Nath SK et al (2014) Poorer prognosis of African-American patients with Mycosis fungoides: an analysis of the SEER dataset, 1988 to 2008 Clin Lymphoma Myeloma Leuk 14:419-423
  4. Quaglino P et al (2012) Time course, clinical pathways, and long-term hazards risk trends of disease progression in patients with classic mycosis fungoides: a multicenter, retrospective follow-up study from the Italian Group of Cutaneous Lymphomas. Cancer 118:5830-5839
  5. Yamada Y et al (2013) Complete clinical remission of tumor-stage granulomatous mycosis fungoides after treatment with PUVA, skin electron irradiation, oral etretinate and systemic interferon-γ. Int J Dermatol 52:893-895


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Last updated on: 29.10.2020