Milia multiple eruptive L72.8

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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eruptive milia; Grains of semolina of the skin; multiple eruptive milia

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Polyätiological clinical picture characterized by the eruptive occurrence of 0.1-0.3 cm large, white, follicular horny beads (milia).

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  • Eruptive milia as side effects of therapy with tyrosine kinase inhibitors: The skin changes usually occur 2-20 days after the start of therapy. These include dryness, itching, burning and possibly pain in the first 2 weeks, increased sensitivity to light, keratitis (inflammation of the cornea), fatigue syndrome, maculopapular or pustular rosacea-like exanthema (see Acne medicamentosa) and milia. The milia, which are mainly located in the face, can occur as the sole symptom without further acne-like changes.
  • Eruptive milia of unknown aetiology: These can occur at any age without a traceable cause (localization: face, neck, ears, trunk)
  • Eruptive milia as follicular hamartomas: These are multiple follicular hamartomas that appear in different phases of life. Such hemartomas can be localized (follicular epidermal nevus), plaque-like or linear or disseminated as a partial symptom of complex malformation syndromes (e.g. Brooke-Spiegler syndrome or trisomy 13).

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  • Eruptive milia can be seen at any age as side effects of a therapy
  • Eruptive milia of the adolescents are mainly centrofacial and in the forehead area.
  • A rare form of eruptive milia is observed in middle adulthood (autosomal dominant inheritance?). Preferably located in the face and upper trunk.


Clinical features
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The infant's milia are either already present at birth, or occur during the 1st year of life. They impress as 0.1-0.2 cm large, follicular, whitish, firm, asymptomatic papules, which cannot be removed by simple "wiping over". Healing after a few weeks.

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Corresponding milia by incision of the covering epidermis and expression of the small horny cyst. Abrasive measures can be helpful before.

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  1. Diba VC et al (2008) Multiple eruptive milia in a 9-year-old boy. Pediatrist Dermatol 25:474-476
  2. Gonul M et al (2015) Multiple eruptive milia on scalp. J Eur Acad Dermatol Venereol doi: 10.1111/jdv.13476
  3. Heard MG et al (1971) The familial occurrence of multiple eruptive milia. Birth Defects Orig Artic Ser 7:333-337
  4. Jung SW et al (2015) Multiple eruptive milia and milia en plaque on the hands and feet of a 2-month-old female. J Dermatol 42: 931-93
  5. Kurashige Y et al (2013) Spontaneous multiple eruptive milia in a 91-year-old man. J Dermatol 40: 290-291
  6. Langley RG et al (1997) Multiple eruptive milia: report of a case, review of the literature, and a classification. J Am Acad Dermatol 37: 353-356
  7. Miescher G (1957) Eruptive milia and Brooke's epithelioma adenoides cysticum. Dermatologica 115:712-716
  8. Sharma R et al (2011) Multiple eruptive milia over both external ears. Indian J Dermatol Venereol Leprol 77:519-520
  9. Sambrano BL et al (2013) Eruptive milia secondary to vemurafenib. J Am Acad Dermatol 69:e258-60
  10. Tharini G et al (2012) Congenital hypotrichosis, eruptive milia, and palmoplantar pits: a case report with review of literature. Int J Trichology 4:32-35

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Milia; Multiple eruptive milia;


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Last updated on: 29.10.2020