Mesalazine
Definition
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Half-life
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0,5-2,4 h or 6-9 h (metabolites).
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Pharmacodynamics (Effect)
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Inhibitor of prostaglandin and leukotriene synthesis, anti-inflammatory and immunosuppressive.
Indication
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Chronic inflammatory bowel diseases, aphthae (topical application)
Dosage and method of use
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- Tbl.: 3-4 times/day 500-1000 mg/day p.o.
- Clysmes: 1 time per day before bedtime give the contents of 1 enema bottle as an enema into the intestine.
- Rectal foam: 1 time per day before bedtime 2 sprays (= 10 g foam) into the intestine.
Standard concentration
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Rectal foam: 20%.
Preparations
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Claversal®500mg, Salofalk® 500 mg, Pentasa® 500 mg; 1000 mg
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Prof. Dr. med. Peter Altmeyer