Melarsoprol

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 30.09.2022

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DefinitionThis section has been translated automatically.

Antiprotozoal agent, organic arsenic compound.

Pharmacodynamics (Effect)This section has been translated automatically.

Binding to essential SH groups of enzymes.

Spectrum of actionThis section has been translated automatically.

Trypanosoma brucei gambiense and rhodiense.

IndicationThis section has been translated automatically.

Cerebral stage of sleeping sickness.

Dosage and method of useThis section has been translated automatically.

3 times 0.6-1.2 mg/kg bw/day for 3 days, repeated after 10-21 days Because of the danger of the Herxheimer reaction, treatment is often carried out according to the scheme (see Table 1) in combination with suramin or pentamidine diisethionate.

Undesirable effectsThis section has been translated automatically.

At first administration in 60% fever. Albuminuria, vomitus, myocardial damage, hypertension, colic, Herxheimer reaction, encephalopathy (occurs in 10%, fatal in up to 40%), peripheral neuropathy.

Notice. Because of possible life-threatening complications, the preparation should only be used in the clinic!

ContraindicationThis section has been translated automatically.

None, because of the lethality of the disease.

PreparationsThis section has been translated automatically.

Arsobal, Mel B (available through the international pharmacy)

TablesThis section has been translated automatically.

Dosage of melarsoprol in combination therapies

Day

Preparation

Dose

[mg/kg bw]

Preparation

Dose

[mg/kg bw]

Preparation

Dose

[mg/kg bw]

Kenya/Sambia (Tr. b. rhod.)

Uganda/Tanzania (Tr. b. rhod.)

Ivory Coast (Tr. b. gamb.)

1.

Suramin

5

Suramin

5

Pentamidine i.m.

4

2.

-

-

-

-

-

-

3.

Suramin

10

Suramin

10

Pentamidine i.m.

4

4.

-

-

-

-

Melarsoprol

1,2

5.

Suramin

20

Melarsoprol

1,8

Melarsoprol

2,4

6.

-

-

Melarsoprol

2,2

Melarsoprol

3,6

7.

Melarsoprol

0,36

Melarsoprol

2,56

-

-

8.

Melarsoprol

0,72

-

-

-

-

9.

Melarsoprol

1,1

-

-

-

-

10.

-

-

-

-

-

-

11.

-

-

-

-

-

-

12.

-

-

-

-

-

-

13.

-

-

-

-

-

14.

-

-

Melarsoprol

2,56

-

-

15.

-

-

Melarsoprol

2,9

-

-

16.

Melarsoprol

1,4

Melarsoprol

3,26

-

-

17.

Melarsoprol

1,8

-

-

Melarsoprol

1,2

18.

Melarsoprol

1,8

-

-

Melarsoprol

2,4

19.

-

-

-

-

Melarsoprol

3,6

20.

-

-

-

-

Melarsoprol

3,6

21.

-

-

-

-

-

-

22.

-

-

-

-

-

-

23.

-

-

Melarsoprol

3,6

-

-

24.

-

-

Melarsoprol

3,6

-

-

25.

Melarsoprol

2,2

Melarsoprol

3,6

-

-

26.

Melarsoprol

2,9

End

-

-

27.

Melarsoprol

3,6

-

-

28.

-

-

-

-

29.

-

-

-

-

30.

-

-

Melarsoprol

1,2

31.

-

-

Melarsoprol

2,4

32.

-

-

Melarsoprol

3,6

33.

-

-

Melarsoprol

3,6

34.

Melarsoprol

3,6

End

35.

Melarsoprol

3,6

36.

Melarsoprol

3,6

End

Authors

Last updated on: 30.09.2022

Author: Prof. Dr. med. Peter Altmeyer