Melanoma cutaneous Images
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Melanoma malignes: slowly growing, completely weightless, brown spot, existing for years. 6 months of central waxing. no wetting of the surface. no bleeding.
Melanoma malignes: Close-up. Bizarre, feathered plaque with rope-like knot formation. No pain at all.
Melanoma malignes (reflected light microscopy, clinical picture see above): Circled still "physiological", net-like structure formation of the melanocytes. Striped junctional melanoma bandages (stars). Grey-blue inflammatory areas with dermal pigment accumulation and inflammatory infiltration (arrows).
Melanoma malignes: reflected light microscopy. arrows: amelanotic tumor proliferations with bizarre "tumor vessels"). encircled unphysiological melanocyte proliferations.
Melanoma malignes: unusually large, for years existing, only very slowly growing, completely symptom-free, brown plaque with irregular regression zones. nodulation circumscribed at the lower pole. no wetting of the surface. no bleeding.
Melanoma malignes superficially spreading: pigmentation mark known and growing for years. No subjective complaints. The melanoma grows asymmetrically (no axial symmetry) with irregular pigmentation and depigmentation zones.
Melanoma malignant superficially spreading: known and growing for years; no subjective complaints; melanoma grows asymmetrically (no axial symmetry) with irregular pigmentation (circled) and depigmentation zones (marked by a square)
Melanoma"type nodular transformed superficial spreading melanoma" : advanced malignant melanoma. black plaque known for several years with increasing, recently rapid thickness growth. repeated wetting and bleeding of the surface. 53 year old patient.
Melanoma "type nodular transformed superficial spreading melanoma": detailed view of an advanced malignant melanoma. black plaque known for several years with increasing, recently rapid thickness growth. repeated wetting and bleeding of the surface. 53-year-old patient.
Melanoma "type nodular transformed superficial spreading melanoma": detailed picture of an advanced malignant melanoma. black plaque known for several years with increasing, recently rapid thickness growth. repeated wetting and bleeding of the surface. 53-year-old patient. arrows mark satellite metases; hexagon marks a regression zone; star marks a progression zone occurring beyond the regression zone.
Melanoma "Type nodular transformed superficial spreading melanoma": detailed picture of an advanced malignant melanoma, largely amelanotic satellite metastasis.
melanoma"type nodular transformed superficial spreading melanoma" : detailed view of the left border zone. a rectangle marks a smooth atrophic, fast growing growth zone. bars mark a largely depigmented regression zone. the hexagon marks a progression zone occurring beyond the regression zone.
Melanoma malignes (Lentigo maligna melanoma): a brown, now black raised area (plaque) that has existed for years with imperceptible growth; no subjective complaints.
Melanoma malignes (overview): initial malignant melanoma, at routine examination as random finding.
Melanoma malignes (overview): small black knot which became noticeable during a "sun holiday".
Melanoma malignes, type SSM: 2.8x 1.8 cm large black plaque with a nodular part on the back; small satellite; inlet close up and reflected light microscopic image.
Melanoma malignes (overview): A continuously growing lump in a 43-year-old man, known for years.
melanoma malignes of the type "lentigo maligna melanoma": irregularlyconfigured brown-black plaque. no subjective complaints. inlet: reflected light micoscopic image.
Differential diagnosis "malignant melanoma": here shown a Spitz nevus (see Spitz nevus below ) in a 3-year-old child; in the upper left corner the light microscopic picture is shown as an inlet.
Melanoma malignes "Type SSM with nodular part": advanced malignant melanoma of the type of superficial spreading melanoma. Thickness growth increasing since 1 year. repeated wetting of the surface. Inlet: optical micoscopic image.
melanoma malignes "type primary nodular melanoma": advanced nodular malignant melanoma. black nodule known for several years with increasing thickness growth. in the last half year faster growth. repeated wetting and bleeding of the surface.
Melanoma malignant "type primary nodular melanoma": advanced nodular malignant melanoma with clearly visible satellite metastases.
Ulcerated melanoma: 8 cm large, nodular ulcerated (largely amelanotic) melanoma on the right flank, growth over 5 years. The patient died 3 months after diagnosis due to cerebral metastasis.
Malignant melanoma, reflected light microscopy
Melanoma malignes (largely amelanotic): due to degradation of the melanin almost pigment-free, symptomless lump; inlet with light-micoscopic detail * Here clumpy pigment remains.
Melanoma malignes, amelanotic: a reddish, locally ulcerated lump on the capillitium that has been present for years and bled for the first time a few weeks ago. Otherwise no other symptoms.
Melanonychia longitudinalis: stripy (melanotic) nail pigmentation caused by a (still benign) pigment nevus localized in the (not visible) nail matrix. The anterior incision edge of the nail plate is pigment-bearing (marked with an arrow). An initial malignant melanoma must be excluded.
Amelanotic acrolentiginous malignant melanoma: slowly growing nodule known for several years; increasing nail destruction in the last six months, also weeping and bleeding, sometimes slight pain; encircled and marked with an arrow, deep-seated pigment remains, which suggest the diagnosis "malignant melanoma".
Melanoma malignes acrolentiginous: permanently growing asymmetric irregularly coloured completely asympotmatic spot that has existed for years.
Melanoma malignes acrolentiginous: Brown "spot" on the left small toe that has existed for many years; for several months now it has been growing in thickness, weeping and bleeding.
Melanoma malignes amelanotisches: acrolentiginous melanoma existing for several years. red (amelanotic) ulcerated nodule growing rapidly since a few months. arrows mark the non-nodular part of the acrolentiginous melanoma
Differential diagnosis of discoloration of the nail: Melanocytic neoplasms of the nail matrix always lead to longitudinal striation of the nail plate.
Melanoma, malignant. Black pigmented node in the conjunctiva of the lateral eye angle.
Malignant melanoma: In the centre of the lesion (encircled) parts of the primary nodular malignant melanoma. Slow peripheral spread with wart-like aspect. Small amelanotic papules marked by arrows, which are not directly anatomically related to the primary tumour (satellite metastases).
Melanoma, malignant, foudroyant, diffuse, cutaneous metastasis around the older operation scar in the area of the thoracic wall; primary tumor: nodular melanoma pT3a; post-operative 3 years ago.
Melanoma, malignant: diffuse, cutaneous metastasis (amelanotic metases) in the area of the thoracic wall; primary tumor: nodular melanoma pT3a; post-operative 2 years ago.
Melanoma malignes: multiple melanoma metastases (see following figure)
Melanoma malignes: multiple melanoma metastases (see circled areas)
Melanoma malignes: multiple cutaneous melanoma metastases in pre-operated nodular melanoma of the lower leg.
Melanoma malignes: Melanoma metastases with halo-like depigmentation of the overlying skin; blue are the deep cutaneous melanoma metastases.
Melanoma malignes (overview): diffuse melanosis in metastatic malignant melanoma.
Malignant melanoma (collision tumor): initial malignant melanoma of the type SSM which partially surrounds a capillary angioma.
Melanoma malignes: the 5 most frequent localisations of malignant melanoma. data from the skin tumour centre Mannheim (2004-2013). cit.n. Lobeck A et al. dermatologist 2017.
melanoma, malignant. presentation of S-100 positive cell formations. S-100 marks both benign and malignant melanocytes. unmarked inflammatory infiltrates between melanocyte nests.
Melanoma, malignant. detailed enlargement sentinel lymph node: lymph node metastasis; microfilia of a malignant melanoma; image with antibodies against S100.
Malignant melanoma on the floor of a dermal nevus cell nevus, reflected light microscopy
Malignant melanoma, laser scanning microscopy: ascending spindle cells and pagetoid cells in the epidermis
Malignant melanoma on the floor of a dermal nevus, laser scanning microscopy
Malignant melanoma, laser scanning microscopy: abolition of the regular annular architecture of the junctional zone, interspersed with spindle cells
Malignant melanoma, laser scanning microscopy: Junction zone interspersed with spindle cells
Malignant melanoma, laser scanning microscopy, pagetoid cells in the epidermis, overview
Melanoma, laser scanning microscopy, pagetoid cells in the epidermis, detail
