Melanoma animal-type C43.L

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Animal-type melanoma; Melanoma malignant melanophages type; Melanoma Melanophagus type

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Rare variant of a malignant melanoma, with a distinct histological pattern. The term "animal-type" was chosen because this melanoma type occurs in horses (grey horse) or in melanomas induced by animal experiments.

Clinical features
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Circumscribed blue-black lump or plaque with a smooth surface, without the brown discoloration of the tumor surface usually observed in malignant melanomas. The clinical picture is similar to the blue nevus.

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The histological picture is characterized by a diffuse accumulation of dense melanophagous turf in the upper and middle, possibly also deep dermis. On closer inspection, large epithelioid melanocytes with polymorphic nuclei and dense pigmentation are found between the melanophages. Mitoses are distributed over the entire tumor parenchyma. Focal lympho-histiocytic infiltrates.

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Due to the rarity of the tumours, it has not yet been possible to obtain prognostic data that deviate from the epidemiological data of conventional malignant melanomas. Metastases were observed.

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  1. Crowson AN et al (1999) Malignant melanoma with prominent pigment synthesis: "animal type" melanoma? A clinical and histological study of six cases with a consideration of other melanocytic neoplasms with prominent pigment synthesis. Hum Pathol 30: 543-550
  2. Requena L et al (2001) Animal type melanoma: a report of a case with balloon-cell change and sentinel lymph node metastasis. At J Dermatopathol 23: 341-346
  3. Zembowicz A et al (2004) Pigmented epithelioid melanocytoma: a low-grade melanocytic tumor with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus. Am J Surg pathogen 28: 31-40


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Last updated on: 29.10.2020