Synonym(s)
Melanotropins; MSH
DefinitionThis section has been translated automatically.
A group of peptide hormones formed in the hypothalamus and intermediate pituitary lobes which activate the same group of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). They are processed from the protein proopiomelanocortin (POMC). MSH regulate melanin synthesis in melanocytes, melanocyte expansion and pigment dispersion. They also limit fever reactions and are involved in the regulation of hunger and sexual functions.
ClassificationThis section has been translated automatically.
The group of melanotropins (MSH) form:
- alpha-MSH
- beta-MSH
- gamma-MSH.
- ACTH.
Note(s)This section has been translated automatically.
A synthetic MSH analogue, Bremelanotide, was in clinical development because of its aphrodisiac effect (erectile dysfunction). Another MSH analogue, Melanotan for skin tanning is currently still in clinical development but is illegally marketed as a tanning agent in various countries.
Prof. Dr. med. Peter Altmeyer