Lymphoepithelioma-like carcinoma C44.4

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Carcinoma Lymphoepithelioma-like; lymphoepithelioma-like carcinoma of the skin

History
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Swanson SA, 1988

Definition
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Rare, largely undifferentiated variant of a spinocellular squamous cell carcinoma with a characteristic fine-tissue mixed cell (lymphoepithelial) structure.

Etiopathogenesis
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Extracutaneous lymphoepithelioma-like carcinoma is often associated with the Epstein-Barr virus. There is a relationship to type III nasopharyngeal carcinoma (old name = Schmincke tumor).

Manifestation
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Occurrence mainly in older people 50-80 years

Localization
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Preferably affected are light-exposed areas such as the head and neck.

Clinical features
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The clinical picture shows an unspectacular skin-colored to slightly reddened solid node of 0.5-1.0 cm in size. Lymph node metastases are rare. Metastases in the liver, lungs or skeleton are equally rare. Uncharacteristic coincidental finding.

Histology
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Mostly well delimitable dermal tumor consisting of plump epithelial strands, in places with ductal structures (CEA-positive), of irregular, in places light-cell epithelial cells mixed in and surrounded by dense infiltrates of mature lymphocytes (T cells) and plasma cells.

Differential diagnosis
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Metastasis of nasopharyngeal lymphoepithelial carcinoma; cutaneous lymphoma; basal cell carcinoma. Merkel cell carcinoma

Therapy
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Excision with a safety distance of at least 1 cm with subsequent radiotherapy.

Literature
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  1. Ko T et al (1997) Lymphoepithelioma-like carcinoma of the skin. J Dermatol 24: 104-109
  2. Lind AC et al (1999) Lymphoepithelioma-like carcinoma of the skin with apparent origin in the epidermis--a pattern or an entity? A case report. Cancer 85: 884-890
  3. Oliveira CC et al (2018) Lymphoepithelioma-like carcinoma of the skin. To Bras Dermatol 93:256-258.
  4. Sagatys E et al (2003) Lymphoid lost and found. On J Dermatopathol 15: 159-161
  5. Shek TW et al (1996) Lymphoepithelioma-like carcinoma of the skin. At J Dermatopathol 18: 637-644
  6. Swanson SA et al (1988) Lymphoepithelioma-like carcinoma of the skin. Mod Catholic 1: 359-365

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020