Lopinavir
Definition
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Pharmacodynamics (Effect)
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Inhibitor of the HIV-associated protease.
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Indication
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Combination therapy of HIV infection.
Dosage and method of use
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- Adults and adolescents: 2 times/day 2 tablets (400 mg Lopinavir/100 mg Ritonavir); alternatively 2 times/day 5 ml solution. (juice).
- Children > 2 years: according to the manufacturer's technical information.
Undesirable effects
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Diarrhea, weakness, fatigue, headache, nausea, pancreatitis, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, lipodystrophy syndrome.
Notice! In case of liver diseases, e.g. hepatits B or C, there may be a deterioration of liver function.
Interactions
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Interactions are possible with simultaneous use of triazolam, astemizole, pimozide, dihydroergotamine, cisapride, propafenone, terfendadine, flecainide, midazolam, rifampin, St. John's wort.
Preparations
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Kaletra (combination with ritonavir)
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Prof. Dr. med. Peter Altmeyer