Lopinavir

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Pharmacodynamics (Effect)
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Inhibitor of the HIV-associated protease.

Indication
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Combination therapy of HIV infection.

Dosage and method of use
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  • Adults and adolescents: 2 times/day 2 tablets (400 mg Lopinavir/100 mg Ritonavir); alternatively 2 times/day 5 ml solution. (juice).
  • Children > 2 years: according to the manufacturer's technical information.

Undesirable effects
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Diarrhea, weakness, fatigue, headache, nausea, pancreatitis, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, lipodystrophy syndrome.

Notice! In case of liver diseases, e.g. hepatits B or C, there may be a deterioration of liver function.

Interactions
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Interactions are possible with simultaneous use of triazolam, astemizole, pimozide, dihydroergotamine, cisapride, propafenone, terfendadine, flecainide, midazolam, rifampin, St. John's wort.

Preparations
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Kaletra (combination with ritonavir)

Incoming links (2)

Fosamprenavir; Virustatics;

Outgoing links (2)

Ritonavir; Virustatics;

Authors

Last updated on: 29.10.2020