Liquor carbonis detergens

Author: Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

Synonym(s)

Coal tar solution; Ethanol-containing zinc oxide shaking mixture with coal tar solution 5-10%. (NRF 11.5.); Head ointment LCD-salicylic acid containing; LCD; LCD cream 2-5%; LCD Cream 5/10 or 20 (NRF 11.86.); LCD emulsion 2%; Liq.carb.deterg.; Liq. carb. deterg. (nach DAC); Lithanthracis picis liquor; Lithantracis picis liquor; Zinc oxide shaking mixture Ethanol containing with coal tar solution 5-10%. (NRF 11.5.)

Definition
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Highly purified preparation of Pix lithanthracis (mixture of phenols, aromatics, N-containing compounds, hydrocarbons) which is prepared with an alcoholic extract of soap bark.

Indication
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Psoriasis vulgaris, eczema, pruritus.

Notice! Only use under doctor's supervision!

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Soap bark

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Standard concentration
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5-20% in ointments, creams and gels, see also Pix. 5-10% in tinctures, 0.5-3% as a washable preparation for use on the scalp. The upper recommended concentration is 20%!

Interactions
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The incorporation of Liquor carbonis detergens into lipophilic bases generally leads to unstable preparations. This is caused, among other things, by saponins which occur in the soap bark and have surface-active (foaming) properties. Together with alcohol they disturb the function of the emulsifier at the interface of the hydrophilic and lipophilic phase.

In hydrophilic creams and emulsions (e.g. Unguentum emulsificans aquosum) there are no compatibility problems with Liquor carbonis detergens.

Liquor carbonis detergens is miscible with 70% ethanol, also miscible with water in the ratio 1:2 to 1:9.

Recipe(s)
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R153 R155 R238 R293 R154 R152

Other magistral formulations:

Hydrophilic Liquor carbonis detergens -Triclosan - Cream
- Liquor carbonis detergent 2,0
- triclosan 3,0
- Ung. emulsific. aquos. (DAB) ad 100,0
- Usage period: 1 year (tube); 6 months (dispenser box)

Note(s)
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The application should be made under consideration of the carcinogenic risk and possible alternatives. The application should be limited to 4 weeks with daily application. With interval application (e.g. in a shampoo), longer application is possible.