Lipoma chondroides

Rare, benign, slow-growing, painless adipose tissue tumor located in deep soft tissue or subcutaneously, showing aspects of both embryonic adipose tissue and embryonic cartilage tissue.

Adult women are affected predominantly, children less frequently.

Extremities, rarely trunk or head and neck area, oral cavity (tongue)

Lobular, encapsulated tumour consisting of mature adipocytes, numerous lipoblasts and granular, multivacuolar eosinophil cells embedded in a partly myxoid, partly chondroid stroma. Often a chromosomal t(11;16)(q13;p13) translocation with a C11orf95-MKL2 fusion is detectable.

1. Choi DL et al (2013) A painless right supraclavicular mass. Chondroid lipoma (CL). JAMA Otolaryngol Head Neck Surg 139:1069-1070.
2. Flucke U et al (2013) Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases. Histopathology 62: 925-930.
3. Thway K et al (2012) Chondroid lipoma: an update and review. Ann Diagn Pathol 16:230-234.
4. Villarroel Dorrego M et al (2014) Chondroid lipoma of the tongue: a report of two cases. Oral Maxillofac Surgery 18:219-222.
5. Yaranal PJ et al (2013) Chondroid lipoma of the thigh: a report of two cases. Indian J Pathol microbiol 56:464-465.