Lipoatrophy, localized after glucocorticosteroid injections T88.7

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 12.05.2021

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Synonym(s)

Cortisone atrophy; Fatty tissue atrophy; Fatty tissue loss; Glucocorticosteroid lipodystrophy; Lipatrophy; localized lipatrophy; localized lipatrophy after medication; localized lipodystrophy; Steroid atrophy

Definition
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Mostly reversible atrophy of cutis and subcutis after injection of glucocorticoid crystal suspension; rarely also after application of fluorinated glucocorticosteroids in occlusive dressing. Pancreatic panniculitis also heals under laoclized adipose tissue atrophy.

Etiopathogenesis
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Especially in combinations of glucocorticoid injections with pressure, e.g. occurring in keloid treatment, in some cases a stronger crystal suspension density seems to play a role in case of incorrect injection technique (too low in intradermal or too high in intramuscular injection).

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Manifestation
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Almost exclusively observed in women or girls, less frequently in male adolescents.

Localization
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Place of injection, usually thigh, buttocks or upper arm.

Differential diagnosis
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Therapy
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Waiting. Mostly regression within 1-3 years. Residual skin atrophy with hypopigmentation and telangiectasia.

Progression/forecast
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Mostly regression within 1-3 years.

Literature
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  1. Süss R et al (1992) Skin atrophy after intralesional glucocorticosteroid injection under the image of linear circumscript scleroderma. Act Dermatol 18: 247-248

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Last updated on: 12.05.2021