Ligand

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Term used in biochemistry for a molecule that can bind to a target protein, for example a receptor. The binding of the ligand is usually reversible and is made possible in particular by ion bonds, hydrogen bonds and Van der Waals forces. The affinity of a ligand to the target protein varies. In contrast to substrates, ligands are not converted by the target molecule, but can influence its three-dimensional structure and function. Ligands that activate a receptor are called agonists, ligands that inactivate a receptor are called antagonists.

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Last updated on: 29.10.2020