Knockout mouse

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Mice (experimental animals) in which certain genes have been specifically switched off using molecular biological methods.

General information
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Molecular genetic manipulations are performed on embryonic stem cells (of mice), which are then introduced into the germ line of a mouse. Knockout mice are now available for a wide range of research areas. With the help of the genetically modified animals, biological mechanisms can be investigated ( angiogenesis). They are also suitable as models for human diseases or for pharmacological questions (research into the pathogenesis and therapy of many skin diseases, e.g. psoriasis).

Literature
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  1. Elmets CA (2006) An animal model of psoriasis in mice deficient in epidermal Jun proteins. Arch Dermatol 142: 1499-1500
  2. Lin EY et al (2006) Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 66: 11238-11246

Incoming links (2)

Angiogenesis; Angiogenesis;

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Last updated on: 29.10.2020