Keratosis palmoplantaris with spiky keratoses

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

punctate keratoderma; Spike-like keratosis palmo-plantaris; Spiny Hyperkeratosis palmaris et plantaris; Spiny keratoderma of the palms and soles

Definition
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Rare palmoplantar keratosis of the palms of the hands and soles of the feet characterized by multiple, symptomless, skin-colored, spike-like, spiky hyperkeratoses about 0.1 cm in size.

Clinical features
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2 forms are distinguished:

  1. The hereditary, autosomal dominant form, which manifests itself between the age of 12 and 50. It can be accompanied by recurrent hypertension, left concentric heart hypertrophy. Accompanying hyperlipidemia has also been described.
  2. The acquired, late-manifested form, which occurs after the age of 50 and may be associated with malignancies. Renal, rectal, mammary and bronchial carcinomas have been described in association. Associations with type IV hyperlipoproteinemia, chronic renal insufficiency, myelofibrosis and polycystic kidneys are also suspected.

Histology
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Compact hyperkeratosis, interspersed with vertically aligned parakeratosis cones.

Therapy
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A successful therapy does not exist. Symptomatic local therapy.

Note(s)
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The dermatological indication of a possible systemic disease is decisive.

Literature
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  1. Baratli J et al (2012) Spiny hyperkeratosis palmaris et plantaris. Dermatologist 63: 923-926
  2. Chee SN et al (2017) Spiny keratoderma: case series and review. Int J Dermatol 56:915-919.

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020