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Isoniazid

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

INAH; INH; Isoniazidium; Isonicotinic acid hydrazide

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DefinitionThis section has been translated automatically.

Tuberculostatics.

Half-lifeThis section has been translated automatically.

2.2-7.5 h (slow acetylators), 0.6-2 h (fast acetylators) S.a. under N-acetyltransferases

IndicationThis section has been translated automatically.

Agent of choice in tuberculosis, only in combination therapies (rapid development of resistance in monotherapy).

Limited indicationThis section has been translated automatically.

Disorders of hematopoiesis.

Dosage and method of useThis section has been translated automatically.

5 mg/kg bw/day p.o. or i.v. for at least 6 months. Children: 10-15 mg/kg bw.

Remember! During pregnancy a combination with ethambutol and rifampicin is possible!

Undesirable effectsThis section has been translated automatically.

Fever, BB changes, gynecomastia, gastrointestinal disorders, liver damage, allergic reactions, drug-induced lupus erythematosus, headaches, dizziness, paresthesias, arthralgias.

InteractionsThis section has been translated automatically.

s. Table 1.

ContraindicationThis section has been translated automatically.

Psychoses, epilepsy, liver and kidney diseases.

PreparationsThis section has been translated automatically.

Isozide, Tebesium

TablesThis section has been translated automatically.

Significant interactions of isoniazid

Alcohol	Alcohol Tolerance ↓
Antiepileptic drugs	Effect of the antiepileptic drugs ↑
β blocker	Isoniazid mining ↓
Carbamazepine	Carbamazepine levels ↑
Insulin	Isoniazid levels ↑
Phenytoin	Phenytoin effect ↑
protionamide	Protionamide levels ↑

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer