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Lupus erythematosus (overview)L93.-
Synonym(s)
HistoryThis section has been translated automatically.
The term lupus was used primarily to characterize scarring skin lesions occurring primarily on the face. In 1828, Biett first described the clinical features of lupus erythematosus (LE), and in 1850, his student Cazanave contributed the name "lupus erythematosus." In 1872, Moriz Kaposi mentioned that systemic LE and chronic discoid lupus were one and the same disease. In 1934, O'Leary introduced the classification of LE that is still in use today. This included discoid LE (DLE), usually confined to the skin, acute disseminated LE (usually fatal), and subacute disseminated LE (usually benign).
DefinitionThis section has been translated automatically.
Mono- or polytopic, complex autoimmune disease (see also autoantibodies) with a predominantly polygenic disposition characterised by an incorrect elimination of extracellular antigens. This leads to a loss of tolerance and a consecutive pathological immune stimulation with specificity for the body's own antigens.
ClassificationThis section has been translated automatically.
Main forms:
LaboratoryThis section has been translated automatically.
Occurrence of autoantibodies in various autoimmune diseases Autoimmune diseases
| Disease patterns and common targets of autoantibodies (antigens) | |
| Disease pattern | Autoantibodies or antigens |
| Anti-phospholipid antibody syndrome (APS) | Lupus anticoagulant, cardiolipin, ß2-glycoprotein |
| Graves' disease, M. | TSH receptor |
| Chronic polyarthritis (rheumatoid arthritis) | Rheumatoid factor, ANA, histones, ssDNA, fillaggrin |
| CREST syndrome | Centromere (ACA) |
| Enteritis regionalis (Crohn's disease) | ASC |
| Dermatitis herpetiformis Duhring | Endomysium, gliadin, epidermal tissue transglutaminase |
| Dermatomyositis/Polymyositis | PM-Scl, Jo-1, MI2, ssDNA, Ku |
| Mixed Connective Tissue Disease | n-RNP, ss-DNA |
| Pemphigoid | BPAG 1 (BP 230), BPAG 2 (BP 180), Epiligrin |
| Pemphigus | desmoglein 1, desmoglein 3, plakoglobin, STAG |
| periarteritis nodosa | p-ANCA, MPO |
| Systemic scleroderma or circumstrictive scleroderma | SCL-70, ACA |
| Sjögren's syndrome | SS-A, SS-B, rheumatoid factor, salivary gland excretory ducts |
| Systemic lupus erythematosus (SLE) | ds-DNA, ssDNA, Sm antigen, SS-A, SS-B |
| Drug-induced SLE | ss-DNA, Histones |
| Wegener's granulomatosis | c-ANCA, PR3 |
| Sprue, Celiac disease | endomysium, gliadin, tissue transglutaminase |
LiteratureThis section has been translated automatically.
- Cazenave PL (1850) Des principales formes du lupus et de son traitement. Gazette of the hôpitaux (Paris) 3 sér. 2: 393
- Cazenave PL (1850) Des principales formes du lupus et de son traitement. Gazette of the hôpitaux (Paris) 3 sér. 4: 114
- Günther C (2015) Genetics of lupus erythematosus. dermatologist 66: 121-130
- Leloir HC (1890) Recherches sur l'histologie pathologique et al nature du lupus érythémateux. Annales de dermatologie et de syphilographie (Paris) 1: 708-709