Inosine
Synonym(s)
Dimepranol; Dimepranol acetamidobenzoate
Definition
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Synthetic derivative of purine with immunomodulatory and virustatic properties. Intermediate product of purine metabolism (purine nucleoside). Effectiveness is controversial.
Indication
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For immune stimulation in viral diseases, especially subacute sclerosing panencephalitis, herpes simplex, zoster, measles, cytomegaly and Epstein-Barr virus infection.
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Pregnancy/nursing period
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Strict indication position! There is no sufficient experience with pregnant women or mothers in the lactation period.
Dosage and method of use
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- Herpes simplex infections: adults 6-8 tbl/day depending on the severity of the disease (one tbl every 2-3 hours), children 1/2-6 tbl spread over several doses throughout the day (50-100 mg active substance/kg bw/day).
- Viral infections in immunocompromised patients: adults: 50 mg divided into 3-5 doses, children 100 mg active substance mixture/kg bw/day divided into 2-4 doses.
Undesirable effects
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Contraindication
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Purine metabolism disorders (gout, hyperuricemia), renal insufficiency, urinary and kidney stone disorders, tendency to extrasystoles, cerebral seizure disorders, gastric disorders, autoimmune disorders and celiac disease.
Preparations
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Isoprinosines