Ini-1

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

hSNF5; SMARCB1

Definition
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Tumor suppressor Gene coding for a subunit of the "SWI/SNF chromatin remodeling complex". The encoded protein INI-1 was first described in the childhood malignant rhabdoid tumor. It is expressed in renal carcinoma and epithelioid sarcoma. It is also expressed in peripheral epithelioid malignant nerve sheath tumors and myoepithelial carcinoma.

Literature
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  1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer Publishing House Berlin-Heidelberg p. 30.
  2. Hollmann TJ et al (2011) INI1-deficient tumors: diagnostic features and molecular genetics.
    Am J Surg Pathol 35:e47-63

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Last updated on: 29.10.2020