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Indinavir
Definition
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Pharmacodynamics (Effect)
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Inhibitor of the HIV-associated protease.
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Indication
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Combination therapy of HIV infection.
Limited indication
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Nephrolithiasis and hyperuricemia in medical history, pregnancy, children.
Dosage and method of use
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- 3 times/day 800 mg p.o. as mono-protease inhibitor.
- Combination therapy with ritonavir: 2 times/day 400 mg indinavir + 2 times/day 100 mg ritonavir p.o.
Undesirable effects
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Kidney pain and stones, hyperbilirubinemia > 2.5 mg/l, insomnia, pharyngitis, dry skin, altered taste perception.
Notice! Stop therapy if hyperbilirubinemia > 5 mg/l.
Interactions
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When taking ketoconazole, reduce the dose of indinavir to 3 times/day 600 mg p.o.; when taking rifabutin in parallel, reduce rifabutin by half.
Preparations
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Crixivan
Patientinformation
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Remember! High liquid intake (min. 3 litres/day). Take 1 hour before or 2 hours after meals. Exception: light breakfast with cornflakes, milk, sugar, coffee!
Literature
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- Eron JJ JR. (2002) HIV-1 protease inhibitors. Clin Infect Dis 30: 160-170
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Prof. Dr. med. Peter Altmeyer