Immunotherapy, specific, oral, tablet therapy

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Grazax

Definition
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Allergen preparation for sublingual immunotherapy for grass pollen allergy.

Indication
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For the treatment of grass pollen-induced pollinosis or rhinoconjunctivitis allergica in adults when SCIT is not an option.

Limited indication
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  • Fish Allergy
  • Tooth extractions or other operations in the oral cavity within the last 7 days before the start of treatment.

Pregnancy/nursing period
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Treatment not recommended during pregnancy, currently no reliable data available for use during lactation.

Dosage and method of use
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1 x/day 1 tbl. p.o.; therapy start 4 months before the start of the grass pollen season. Therapy is then continued during the grass pollen season.

Undesirable effects
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  • Side effects are usually temporary and occur as oral allergy syndrome restricted to the oral cavity. The risk of systemic or serious side effects is less than with SCIT.
  • According to manufacturer's information/study results:
    • Particularly common: facial itching, neck irritation, sneezing, itching and swelling of the neck.
    • Common: conjunctivitis, rhinitis, angioedema, clinical symptoms of tonsillitis, pulmonary symptoms, dyspnea, gastrointestinal symptoms. Coughing, disturbance of general well-being (fatigue).
    • Occasionally: urticaria, pain and inflammation of the mouth, blisters on the lips.

Contraindication
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  • Hypersensitivity to components of the tablet.
  • Diseases of the immune system.
  • Severe bronchial asthma.
  • Malignant diseases.
  • Inflammations in the oral cavity.

Preparations
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Grazax (ALK-Scherax)

Note(s)
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Grazax contains allergens from grass pollen of timothy grass (Phleum pratense).

Literature
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  1. Dahl R et al (2006) Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 118: 434-440

Incoming links (2)

Grazax; Slit;

Authors

Last updated on: 29.10.2020