Histidine-rich glycoprotein

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

HRGP

Definition
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HRGP is an antagonist of fibrinolysis, which is produced in the thrombocytes (see below fibrinolysis antagonists). It binds to fibrin and fibrinogen. HRGP is a competitive inhibitor of plasminogen due to its high binding capacity to the lysine binding sites. This inhibits fibrinolysis. 50% of the plasminogen and alpha-2-antiplasmin are bound to the HRGP.

Literature
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  1. HA Neumann (2014) The coagulation system. ABW-Wissenschaftsverlag GmbH Berlin p. 113.

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Last updated on: 29.10.2020