Synonym(s)
Heparin-induced platelet activation; Heparin-induced platelet aggregation
DefinitionThis section has been translated automatically.
Detection of platelet activation in the presence of heparin or heparin derivatives.
IndicationThis section has been translated automatically.
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ImplementationThis section has been translated automatically.
Incubation of platelets from healthy donors in a microtiter plate with the serum to be tested and with heparin. Platelet activation leads to sedimentation of the thrombocytes, optical measurement is used to detect the antigen-autoantibody complex.
Note(s)This section has been translated automatically.
At the same time, the test also allows a statement to be made in vitro about the compatibility of alternative preparations.
LiteratureThis section has been translated automatically.
- Greinacher A et al (1991) A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb haemost 66: 734-736
- Greinacher A, Juhl D, Strobel U, Wessel A, Lubenow N, Selleng K, Eichler P, Warkentin TE (2007) Heparin-induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes. J Thromb Haemost 5: 1666-1673
- Warkentin TE (2007) Heparin-induced thrombocytopenia. Hematol Oncol Clin North Am 21: 589-607
- Warkentin TE, Mason BT, Aster RH (2007) Heparin-induced thrombocytopenia associated with fondaparinux. N Engl J Med 356: 2653-2655
Prof. Dr. med. Peter Altmeyer