Hidradenoma papilliferum D23.L

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Adenoma of the vulva tubular; Tubular adenoma of the vulva; vulvar hidradenoma

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Kaposi, 1874

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Rare, benign adnexal tumor (of the female genital area) with apocrine differentiation.

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Postpubertal, especially 3rd and 5th decade of life.

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Mainly vulva, inner labia, perineum. Rarely extragenitally located, mostly on the eyelid, auditory canal, bridge of the nose, chest region. Very occasionally also observations in men on the prepuce.

Clinical features
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Intradermal or subcutaneously located, mostly solitary, 0.5-1.0 cm large, bulging, elastic, slowly growing tumor. Pressure atrophy of the overlying epidermis in larger tumours with light red granular granulations on the surface. Ulceration possible.

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Cystic, well defined dermal tumor without relation to the ceiling epithelium. Parenchyma consisting of tubular and papillary complexes enclosing small or larger accumulations of secretions. Epithelium of large cylindrical cells with pale eosinophilic cytoplasm and uniform basophilic nuclei. In ductal sections the epithelia may show the decapitation sign typical of apocrine secretion. No mitoses.

Differential diagnosis
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Rarely malignant degeneration or development of Paget's disease over a Hidradenoma papilliferum.

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Extirpation under local anesthesia without safety distance.

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  1. Aktepe F et al (2003) Tubular apocrine adenoma in association with syringocystadenoma papilliferum. Dermatol Online J 9: 7
  2. Handa Y et al (2003) Large ulcerated perianal hidradenoma papilliferum in a young female. Dermatol Surgery 29: 790-792
  3. Hsu PJ et al (2003) Mixed tubulopapillary hidradenoma and syringocystadenoma papilliferum occurring as a verrucous tumor. J Cutan pathogen 30: 206-210
  4. Kaposi M (1874) Hebra diseases of the skin. Lymphangioma tuberosum multiplex. The New Sydenham Society (London) 3: 386
  5. Lee HJ et al (2002) Nevus comedonicus with hidradenoma papilliferum and syringocystadenoma papilliferum in the female genital area. Int J Dermatol 41: 933-936
  6. Massad LS (1996) Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection. Gynecol Oncol 61: 287-290
  7. Omole F et al (2003) Management of Bartholin's duct cyst and gland abscess. On Fam Physician 68: 135-140
  8. Smith FB et al (2003) Hidradenoma papilliferum of nasal skin. Arch Pathol Lab Med 127: 86-88
  9. Stefanato CM et al (2000) Extramammary Paget disease with underlying hidradenoma papilliferum: guilt by association? On J dermatopathy 22: 439-442
  10. Tanaka M, Shimizu S (2003) Hidradenoma papilliferum occurring on the chest of a man. J Am Acad Dermatol 48: 20-21
  11. Virgili A et al (2000) Vulvar hidradenoma papilliferum. A review of 10.5 years' experience. J Reprod Med 45: 616-618


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Last updated on: 29.10.2020