Grinspan syndrome L43.8

Diabetes mellitus; hypertension; oral lichen planus;

Grinspan syndrome (GS) is characterized by an association of diabetes mellitus, hypertension and oral lichen planus (Lamey PJ et al.1990).

It is still unclear whether this is an independent disease or a lichenoid reaction as a result of taking medication to treat high blood pressure and diabetes.

A rare association of Grinspan syndrome with pemphigus vulgaris is noteworthy. In one case, this clinical constellation was triggered by a COVID-19 vaccination. (Saddik A et al. 2025).

1. Kökten N et al. (2018) Grinspan's Syndrome: A Rare Case with Malignant Transformation. Case Rep Otolaryngol 2018:9427650
2. Lamey PJ et al.(1990) Grinspan's syndrome: a drug-induced phenomenon? Oral Surg Oral Med Oral Pathol 70:184-185
3. Saddik A et al. (2025) Grinspan Syndrome Associated With Pemphigus Vulgaris Induced by COVID-19 Vaccination. Cureus 17:e88255.