Gabapentin

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Anticonvulsant and antiepileptic.

Pharmacodynamics (Effect)
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Gabapentin inhibits HVA calcium channels and thus blocks the influx of Ca++ ions into neurons of the CNS.

Indication
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Seizures of focal origin; prurigo nodularis and neuropathic pruritus.

Dosage and method of use
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  • Adults: Initially start with 300 mg p.o. 3 times/day, if necessary increase every 1-3 days by 300 mg/day. Maintenance dose: 900-2400 mg/day, if necessary increase up to 3600 mg/day
  • Children and teenagers > 12 years. Start initially with about 50 % of the maintenance dose. If necessary increase every 1-3 days up to the maximum dose. Maintenance dose: 30--50 mg/kg/day.

Undesirable effects
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Fatigue, ataxia, weakness, somnolence double vision, dizziness nystagmus, headache, tremor.

Interactions
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Drug interactions: So far, no clinically relevant interactions are known.

Preparations
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Gabax, Neurontin

Note(s)
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  • Gabapentin is characterized by its rapid dosage and the minor interactions with other drugs. Compared with other anticonvulsants, it therefore has advantages in the treatment of multimorbid epilepsy patients in old age.
  • A dose-response principle has not been demonstrated. However, 300 mg/day proved to be significantly less effective than 900 or 1800 mg/day.

Outgoing links (2)

Nodular prurigo; Pruritus;

Authors

Last updated on: 29.10.2020