Epitope spreading

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 18.09.2026

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Keywords
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Cross-Reactivity; Epitope Spreading; De Novo Immune Stimulation; cross-reaction; epitope spreading; determinant spreading; 

History
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An immunological phenomenon that Miller demonstrated 20 years ago in animal models.

Literature
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  1. Attili VR et al(2015) Acral Vitiligo and Lichen Sclerosus - Association or a Distinct Pattern? A Clinical and Histopathological Review of 15 Cases. Indian J Dermatol 60:519.
  2. Cornaby C et al(2014) B cell epitope spreading: mechanisms and contribution to autoimmune diseases. Immunol Lat 163:56-68.
  3. Nakagawa M et al,(2015) Cross-Reactivity, Epitope Spreading, and De Novo Immune Stimulation Are Possible Mechanisms of Cross-Protection of Nonvaccine Human Papillomavirus (HPV) Types in Recipients of HPV Therapeutic Vaccines. Clin Vaccine Immunol 22:679-687.

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Last updated on: 18.09.2026